Carotid intima‐media thickening is induced by low flow: roles for IL‐18 and Mif
نویسندگان
چکیده
منابع مشابه
Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening.
OBJECTIVE Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an important predictive factor for human cardiovascular disease. We characterized a mouse model of vascular remodeling. METHODS AND RESULTS The left external and internal carotid branches were ligated so that left carotid blood flow was reduced to flow via the occipital artery. In response to partial liga...
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متن کاملGenetic modifier loci linked to intima formation induced by low flow in the mouse carotid.
OBJECTIVE Previously we found dramatic strain-dependent differences in a low flow model of vascular remodeling. Specifically, intima formation in the left common carotid artery was approximately 30-fold greater in SJL compared to C3HeB/Fe (C3H/F) mice. We hypothesized that a few genes control intima formation in response to low flow. A C3H/F and SJL backcross resulted in broad range of N2 intim...
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BACKGROUND AND PURPOSE Lumen geometry has long been suspected as a risk factor for atherosclerosis by virtue of its influence on blood flow disturbances. Confirmation of this geometric risk hypothesis has, however, proved challenging owing to possible effects of wall thickening on geometry and unproven links between candidate geometric variables and disturbed flow. The purpose of this study was...
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In this paper we propose a new computationally efficient algorithm for automatic estimation of intima and media boundary of common carotid artery (CCA) based on ultrasound (USG) image analysis. The intima-media thickness (IMT), equal to distance between intima and media boundary, is typically used to predict cardiovascular events like myocardial infarction and stroke. At present, it is measured...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a198-c